4.7 Article

Multicomponent Synthesis of Diverse o-Arylated Benzamides via o-Aminophenol (OAP) Directed C(sp2)-H Arylation

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 17, Pages 8950-8957

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b01375

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Funding

  1. National Natural Science Foundation of China [21562024, 21562025]
  2. Science Fund for Distinguished Young Scholars of Jiangxi Province [20162BCB23023]

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o-Aminophenol (OAP) has been discovered as practical precursor of directing group (DG) in the palladium-catalyzed aromatic C-H arylation of benzamides. This newly identified, simple, and low cost DG has exhibited broad substrate tolerance in the rapid synthesis of various o-arylated benzamides via direct assemblies of benzoyl chlorides, aryl iodides, and different o-aminophenols in the form of step economical multicomponent reaction.

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