4.7 Article

One-Pot Construction of Functionalized Spiro-dihydronaphthoquinone-oxindoles via Hauser-Kraus Annulation of Sulfonylphthalide with 3-Alkylideneoxindoles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 23, Pages 12939-12944

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b02656

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Funding

  1. SERB, DST India
  2. UGC India
  3. CSIR India

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The Hauser-Kraus annulation of sulionylphthalide with 3-olefinic oxindole has been performed. This strategy, which involves a cascade Michael addition-Die-ckmann cyclization elimination sequence, offers rapid and convenient access to novel spiro-dihydronaphthoquinone-oxindoles in excellent yields with complete selectivity for the enolic form under mild reaction conditions.

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