Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 19, Pages 10408-10417Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b01867
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Funding
- Science Technology Department of Zhejiang Province [LQ15B020002, LQ13B020002]
- NSFC [21172149, 21302129]
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Described herein is a convenient and highly selective synthesis of alkynylated isoquinolines and biisoquinolines from various aryl ketone O-pivaloyloxime derivatives and 1,3-diynes via rhodium-catalyzed C-H bond activation. In this transformations, alkynylated isoquinolines, 3,4'- and 3,3'-biisoquinolines could be obtained respectively through changing the reaction conditions. Mechanistic investigation revealed that the C-H activation of aryl ketone O-pivaloyloxime was the key step to this reaction.
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