Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 4, Pages 1961-1968Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02814
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Funding
- Ministry of Science and Technology of the Republic of China [MOST 103-2113-M-003-008-MY3]
- National Taiwan Normal University [103-07-C]
- Instrumentation Centre at National Taiwan Normal University
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A concise route for the synthesis of indenoisoquinoline derivatives from 2-iodobenzamide and 1,3-indanedione derivatives in the presence of copper(II) chloride and cesium carbonate in acetonitrile solvent is reported. A wide variety of 2-iodobenzamide derivatives and indandiones could be used to synthesize indenoisoquinoline derivatives and other fused indenoisoquinoline in moderate to good yields. This methodology was adapted for the one-step synthesis of a series of clinically active topoisomerase I inhibitors such as NSC 314622, LMP-400, LMP-776.
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