4.7 Article

Palladium-Catalyzed Safe Cyanation of Aryl Iodides with Hexamethylenetetramine

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 23, Pages 12888-12891

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b02373

Keywords

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Funding

  1. National Natural Science Foundation of China [21572025, 21602019]
  2. Innovation and Entrepreneurship Talents Introduction Plan of Jiangsu Province
  3. Natural Science Foundation of Jiangsu Province [BK20171193]
  4. Key University Science Research Project of Jiangsu Province [15KJA150001]
  5. Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]
  6. Advanced Catalysis and Green Manufacturing Collaborative Innovation Center
  7. Young Natural Science Foundation of Jiangsu Province [BK20150263]

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A palladium-catalyzed cyanation of aryl halides with hexamethylenetetramine as a safe cyanide source is achieved, providing aromatic nitriles in moderate to good yields. This approach shows good functional group compatibilities and avoids the use of toxic cyanide source.

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