Journal
NATURE REVIEWS CANCER
Volume 19, Issue 11, Pages 651-661Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41568-019-0198-5
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Funding
- Damon Runyon Cancer Research Foundation [DRG-2299-17]
- Emerald Foundation
- Lustgarten Foundation
- SU2C
- Ludwig Center at MIT
- US National Cancer Institute
- MIT Center for Precision Cancer Medicine
- Howard Hughes Medical Institute
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The way cancer cells utilize nutrients to support their growth and proliferation is determined by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the environment. These interactions can define therapeutic vulnerabilities and impact the effectiveness of cancer therapy. Diet-mediated changes in whole-body metabolism and systemic nutrient availability can affect the environment that cancer cells are exposed to within tumours, and a better understanding of how diet modulates nutrient availability and utilization by cancer cells is needed. How diet impacts cancer outcomes is also of great interest to patients, yet clear evidence for how diet interacts with therapy and impacts tumour growth is lacking. Here we propose an experimental framework to probe the connections between diet and cancer metabolism. We examine how dietary factors may affect tumour growth by altering the access to and utilization of nutrients by cancer cells. Our growing understanding of how certain cancer types respond to various diets, how diet impacts cancer cell metabolism to mediate these responses and whether dietary interventions may constitute new therapeutic opportunities will begin to provide guidance on how best to use diet and nutrition to manage cancer in patients.
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