The Role of Aptamer Loaded Exosome Complexes in the Neurodegenerative Diseases

Extracellular exosomes formed inside the cytoplasm of cells are small membranous vesicles that provide an important mode of cell-to-cell communication by delivering proteins, lipids and RNA to target cells. Exosomes are found associated with neurodegenerative diseases mainly Parkinson's disease (PD) and Alzheimer's diseases (AD), characterized by progressive degeneration of neurons and often linked with misfolded protein. Aptamers are single stranded DNA- and RNA-based oligonucleotides that bind target protein with high affinity and specificity and block or prevent the process of neurodegenerative diseases. In this review, we discuss the role of aptamer loaded exosomes in the neurode-generative diseases.