Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 59, Issue 1, Pages 117-120Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.117.195248
Keywords
F-18-AV-1451; PET; iron; aging; basal ganglia
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Off-target binding in the basal ganglia is commonly observed in the F-18-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R*(2) MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent F-18-AV-1451 PET and R*(2) MRI studies. A correlation analysis was performed for age, F-18-AV-1451 binding, and R*(2) values. Results: There was an age-related increase in both F-18-AV-1451 binding in the basal ganglia and R*(2) values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. F-18-AV-1451 binding in the basal ganglia increased with R*(2) values. Conclusion: Off-target F-18-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.
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