Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 7, Issue 41, Pages 6390-6398Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb00587k
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Funding
- Brazilian agency Fundacao de Apoio a Pesquisa do Distrito Federal (FAP/DF) [0193.001020/2015, 0193.001626/2017]
- Brazilian agency Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [447628/2014-3]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
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The aim of this work was to develop and test the in vitro biological activity of nanocapsules loaded with a doxorubicin (DOX) free base dissolved in a core of castor oil shelled by poly(methyl vinyl ether-co-maleic anhydride) conjugated to n-octadecylamine residues. This system was stable and monodisperse, with a hydrodynamic diameter of about 300 nm. These nanocapsules changed the intracellular distribution of DOX, from the nuclei to the cytoplasm, and exhibited higher toxicity towards cancer cells - 4T1 and MCF-7 - and significantly lower toxicity towards normal cells - NIH-3T3 and MCF-10A - in vitro. In conclusion, these nanocapsules are suitable DOX carriers, which remain to be studied in in vivo tumor models.
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