Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 86, Pages 12956-12959Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc06040e
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Funding
- National Science Foundation of China [21808028]
- Weifang Science and Technology Plan Project [2018GX002]
- Weifang High-tech Zone Science and Technology Plan Project [2019KJHM05]
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A bimetallic complex, containing Mn(ii) and Cu(ii) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.
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