Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 81, Issue 10, Pages 1468-1474Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.19-0125
Keywords
blue eggshell layer; Innate immunity; LSm14A; Newcastle disease viruses
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Funding
- National Natural Science Foundation of China [31460668]
- Technology Foundation of Guizhou [QianKeHe J (2015) 2046]
- Ph.D. foundation of Guizhou University [(2013) 12]
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LSm14A is a key innate immunity component of processing body (P-body) that mediates interferon-beta (IFN-beta) signaling by viral RNA. This is the first study to report chicken LSm14A (cLSm14A) cloning from blue eggshell layer, high tibia and frizzle chickens. The cLSm14A gene, encoding 461 amino acids, is highly homologous in the three types of chickens. The cLSm14A was extensively expressed in several tissues. The transcriptional level of cLSm14A was significantly increased in various stages of Newcastle disease virus (NDV) infection. In HEK293 cells, full length cLSm14A from blue eggshell layer was localized in the cytoplasm as dots. The results of this study indicated that cLSm14A is an important sensor that mediates innate immunity in chicken against NDV infections.
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