Journal
JOURNAL OF NEUROSURGERY
Volume 126, Issue 1, Pages 191-200Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2016.1.JNS151591
Keywords
convection enhanced delivery; glioblastoma; blood-brain barrier; oncology
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Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeutic measure and review preclinical studies and the most prominent clinical trials of CED in the treatment of glioblastoma. The utilization of this technique for the delivery of a variety of agents is covered, and its shortcomings and challenges are discussed in detail.
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