Journal
CHEMICAL SCIENCE
Volume 10, Issue 41, Pages 9586-9590Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc03843d
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Funding
- National Natural Science Foundation of China [21572192, 21490570]
- Hong Kong RGC [16302617, 16302318]
- Shenzhen Science and Technology Innovation Committee [JCYJ20170818113708560]
- Jiangsu specially appointed professors program
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A new catalytic protocol for the expedient synthesis of oxazolines from oxetanes is disclosed. This mild process complements the conventional oxazoline synthesis based on non-catalytic cyclization of beta-hydroxy or unsaturated amides. It is also a new addition to the reactivity profile of oxetanes leading to heterocycles. In the presence of In(OTf)(3), various 3-amido oxetanes underwent smooth intramolecular cyclization to form the corresponding 2-oxazolines, including some valuable oxazoline-based bidentate ligands. This protocol also provides rapid access to various natural products and antibacterial molecules.
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