Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 291, Issue -, Pages 1-12Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2017.08.003
Keywords
Neuroimage correlation analysis; Functional magnetic resonance imaging (fMRI); Temporal correlation (tcorr); Correlation scale invariance; Spatial smoothing; Functional overestimation
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Funding
- National Natural Science Foundation of China [81471738]
- Fundamental Research Funds for the Central Universities
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Background: Pearson correlation (simply correlation) is a basic technique for neuroimage function analysis. It has been observed that the spatial smoothing may cause functional overestimation, which however remains a lack of complete understanding. Herein, we present a theoretical explanation from the perspective of correlation scale invariance. New methods: For a task-evoked spatiotemporal functional dataset, we can extract the functional spatial map by calculating the temporal correlations (tcorr) of voxel timecourses against the task timecourse. From the relationship between image noise level (changed through spatial smoothing) and the tcorr map calculation, we show that the spatial smoothing causes a noise reduction, which in turn smooths the tcorr map and leads to a spatial expansion on neuroactivity blob estimation. Results: Through numerical simulations and subject experiments, we show that the spatial smoothing of fMRI data may overestimate activation spots in the correlation functional map. Our results suggest a small spatial smoothing (with a smoothing kernel with a full width at half maximum (FWHM) of no more than two voxels) on fMRI data processing for correlation-based functional mapping Comparison with existing methods: In extreme noiselessness, the correlation of scale-invariance property defines a meaningless binary tcorr map. In reality, a functional activity blob in a tcorr map is shaped due to the spoilage of image noise on correlative responses. We may reduce data noise level by smoothing processing, which poses a smoothing effect on correlation. This logic allows us to understand the noise dependence and the smoothing effect of correlation -based fMRI data analysis. (C) 2017 Elsevier B.V. All rights reserved.
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