Journal
JOURNAL OF NEUROSCIENCE
Volume 37, Issue 30, Pages 7111-7124Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0260-17.2017
Keywords
declarative memory; mild cognitive impairment; phase-amplitude coupling; sleep; transcranial electrical stimulation
Categories
Funding
- Deutsche Forschungsgemeinschaft [Fl 379-10/1, 379-11/1, SFB 910, DFG-EXC 257]
- Bundesministerium fur Bildung und Forschung [FKZ 01EO0801, 01GQ1424A, 01GQ1420B]
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Alzheimer's disease (AD) not only involves loss of memory functions, but also prominent deterioration of sleep physiology, which is already evident at the stage of mild cognitive impairment (MCI). Cortical slow oscillations (SO; 0.5-1 Hz) and thalamocortical spindle activity (12-15 Hz) during sleep, and their temporal coordination, are considered critical for memory formation. We investigated the potential of slow oscillatory transcranial direct current stimulation (so-tDCS), applied during a daytime nap in a sleep-state-dependent manner, to modulate these activity patterns and sleep-related memory consolidation in nine male and seven female human patients with MCI. Stimulation significantly increased overall SO and spindle power, amplified spindle power during SO up-phases, and led to stronger synchronization between SO and spindle power fluctuations in EEG recordings. Moreover, visual declarative memory was improved by so-tDCS compared with sham stimulation and was associated with stronger synchronization. These findings indicate a well-tolerated therapeutic approach for disordered sleep physiology and memory deficits in MCI patients and advance our understanding of offline memory consolidation.
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