Journal
JOURNAL OF NEUROSCIENCE
Volume 37, Issue 48, Pages 11715-11730Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2664-17.2017
Keywords
computational models; frontal eye fields; reversible inactivation; saccade; superior colliculus
Categories
Funding
- Canadian Institutes of Health Research [MOPs: 93796, 123247, 142317]
- Natural Sciences and Engineering Research Council (NSERC) [RGPIN-311680]
- Ontario Graduate Scholarship
- NSERC Collaborative Research and Training Experience Program grant
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Stochastic accumulator models provide a comprehensive framework for how neural activity could produce behavior. Neural activity within the frontal eye fields (FEFs) and intermediate layers of the superior colliculus (iSC) support such models for saccade initiation by relating variations in saccade reaction time (SRT) to variations in such parameters as baseline, rate of accumulation of activity, and threshold. Here, by recording iSC activity during reversible cryogenic inactivation of the FEF in four male nonhuman primates, we causally tested which parameter(s) best explains concomitant increases in SRT. While FEF inactivation decreased all aspects of ipsilesional iSC activity, decreases in accumulation rate and threshold poorly predicted accompanying increases in SRT. Instead, SRT increases best correlated with delays in the onset of saccade-related accumulation. We conclude that FEF signals govern the onset of saccade-related accumulation within the iSC, and that the onset of accumulation is a relevant parameter for stochastic accumulation models of saccade initiation.
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