Journal
JOURNAL OF NEUROSCIENCE
Volume 37, Issue 39, Pages 9424-9437Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0731-17.2017
Keywords
functional development; functional segregation; higher visual areas; mouse visual cortex; wide-field calcium imaging
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Funding
- Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS), Japan Agency for Medical Research and Development (AMED)
- Core Research for Evolutionary Science and Technology ( CREST), AMED
- Strategic International Research Cooperative Program (SICP), AMED
- Japan Society for the Promotion of Sciences (JSPS) (KAKENHI) [25221001, 25117004, 201204982, 15H06473, 20153597]
- Grants-in-Aid for Scientific Research [15H06473, 25117004, 17K14931] Funding Source: KAKEN
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Recent studies suggest that higher visual areas (HVAs) in the mouse visual cortex are segregated anatomically into two visual streams, likely analogous to the ventral and dorsal streams in primates. However, HVAs in mice have yet to be characterized functionally. Moreover, it is unknown when the functional segregation of HVAs occurs during development. Here, we investigated spatiotemporal selectivity of HV As and their development using wide-field calcium imaging. We found that lateral HV As in the anatomical ventral stream shared similar spatiotemporal selectivity, whereas the spatiotemporal selectivity of anterior and medial HVAs in the anatomical dorsal stream was not uniform and these areas were segregated functionally into multiple groups. This functional segregation of HVAs developed and reached an adult-like pattern similar to 10 d after eye opening (EO). These results suggest, not only the functional segregation of ventral and dorsal streams, but also the presence of multiple substreams in the dorsal stream, and indicate that the functional segregation of visual streams occurs gradually after EO.
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