Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 83, Issue 3, Pages 274-277Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2015.07.012
Keywords
Leprosy; Phenolic glycolipid-I; Major membrane protein-II; Serology
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Funding
- National Natural Science Foundation of China [81371751]
- fund for Natural Science Foundation of Jiangsu Province [2014020044]
- 'Research Program on Emerging and Re-emerging Infectious Diseases' from Japan Agency for Medical Research and development, AMED - US-Japan Cooperative Medical Science Program
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Antibodies, to phenolic glycolipid (PGL)-I and major membrane protein (MMP)-II were evaluated for serodiagnosis of leprosy in Southwest China, and the role in predicting the occurrence of the disease in household contacts (HHCs) of leprosy was examined. Using PGL-I (natural disaccharide-octyl-bovine serum albumin) antigen based diagnosis (IgM antibodies), we could detect 94.9% of multibacillary (MB) leprosy and 38.9% paucibacillaty (PB) leprosy patients, whereas using MMP-II (IgG antibody), 88.1% of MB and 61.1% of PB patients were positive. By combining the 2 tests and considering either test positive as positive, 100% of MB patients and 72.2% of PB patients were found to test positive. Of the HHCs of leprosy, 28.3% and 30% had positive levels of PGL-I and MMP-II Abs, respectively. Seven out of 21 HHCs, who had high Ab titer to either antigen, developed leprosy during the follow-up period of 3 years. These data suggest that the measurement of both anti-PGL-I as well as anti-MMP-II antibodies could facilitate early detection of leprosy. (C) 2015 Elsevier Inc. All rights reserved.
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