Journal
JOURNAL OF NEUROSCIENCE
Volume 37, Issue 12, Pages 3246-3263Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3128-16.2017
Keywords
activity-dependent structural remodeling; Drosophila; integrin; neuromuscular junction; Shriveled; synaptic boutons
Categories
Funding
- National Institutes of Health [NS-080946]
- Alzheimer's Association
- Global Down Syndrome Foundation
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Activity-induced synaptic structural modification is crucial for neural development and synaptic plasticity, but the molecular players involved in this process are not well defined. Here, we report that a protein named Shriveled (Shv) regulates synaptic growth and activity-dependent synaptic remodeling at the Drosophila neuromuscular junction. Depletion of Shv causes synaptic overgrowth and an accumulation of immature boutons. Wefind that Shv physically and genetically interacts with beta PS integrin. Furthermore, Shv is secreted during intense, but not mild, neuronal activity to acutely activate integrin signaling, induce synaptic bouton enlargement, and increase postsynaptic glutamate receptor abundance. Consequently, loss of Shv prevents activity-induced synapse maturation and abolishes post-tetanic potentiation, a form of synaptic plasticity. Our data identify Shv as a novel trans-synaptic signal secreted upon intense neuronal activity to promote synapse remodeling through integrin receptor signaling.
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