Journal
CANCER GENOMICS & PROTEOMICS
Volume 16, Issue 6, Pages 593-601Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/cgp.20162
Keywords
DNA replication; geminin; Oct4; retinoic acid; pluripotency; mir-452; GABA; H2AX
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Funding
- THALES: The role and mechanisms of asymmetric cell division during stem cell differentiation program - European Social Fund (ESF)
- Greek National Funds through the Operational Program Education and Lifelong Learning of the National Strategic Reference Framework (NSFR)
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Background/Aim: Several links between DNA replication, pluripotency and development have been recently identified. The involvement of miRNA in the regulation of cell cycle events and pluripotency factors has also gained attention. Materials and Methods: In the present study, we used the g:Profiler platform to analyze transcription factor binding sites, miRNA networks and protein-protein interactions to identify novel links among the aforementioned processes. Results and Conclusion: A complex circuitry between retinoic acid signaling, SWI/SNF components, pluripotency factors including Oct4, Sox2 and Nanog and cell cycle regulators was identified. It is suggested that the DNA replication inhibitor geminin plays a central role in this circuitry.
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