Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 83, Issue 3, Pages 305-311Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2015.06.005
Keywords
Bacterial meningitis; Neisseria meningitidis; Surveillance; Cerebrospinal fluid; Real-time PCR; 16S
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Funding
- Epidemiology and Laboratory Capacity for Infectious Diseases grant of the Centers for Disease Control and Prevention [ELC ARRA 317-MCV, 3U50C1223667-05S2]
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Confirmed and probable cases of invasive Neisseria meningitidis (Nm) infection are reportable in New York City. We conducted a study to identify Nm among culture-negative reports of bacterial and viral meningitis. During the study period, 262 reports of suspected meningitis were eligible. Cerebrospinal fluid (CSF) specimens from 138 patients were obtained for testing. No Nm cases were detected. Results from real-time polymerase chain reaction and 16S on CSF specimens were concordant with hospital microbiology findings in 80%; however, other pathogenic organisms were detected in 14 culture-negative specimens. New York City's surveillance system appears to be effective at capturing cases of Nm meningitis. Nucleic add testing is useful for detecting the presence of bacterial DNA when antibiotic therapy precedes lumbar puncture or bacterial cultures are negative. It remains unanswered whether culture-negative cases of Nm bacteremia are being missed by reportable disease surveillance. (C) 2015 Elsevier Inc. All rights reserved.
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