Journal
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Volume 88, Issue 11, Pages 971-981Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2016-315500
Keywords
-
Categories
Funding
- NIHR Surgical Reconstruction and Microbiology Research Centre
- UK Medical Research Council
- NIHR Cambridge Biomedical Research Centre (BRC)
- NIHR
- NIHR Cambridge BRC
- National Institute for Health Research [NIHR-RP-R3-12-013] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [NIHR-RP-R3-12-013] Funding Source: National Institutes of Health Research (NIHR)
Ask authors/readers for more resources
Pituitary dysfunction is a recognised, but potentially underdiagnosed complication of traumatic brain injury (TBI). Post-traumatic hypopituitarism (PTHP) can have major consequences for patients physically, psychologically, emotionally and socially, leading to reduced quality of life, depression and poor rehabilitation outcome. However, studies on the incidence of PTHP have yielded highly variable findings. The risk factors and pathophysiology of this condition are also not yet fully understood. There is currently no national consensus for the screening and detection of PTHP in patients with TBI, with practice likely varying significantly between centres. In view of this, a guidance development group consisting of expert clinicians involved in the care of patients with TBI, including neurosurgeons, neurologists, neurointensivists and endocrinologists, was convened to formulate national guidance with the aim of facilitating consistency and uniformity in the care of patients with TBI, and ensuring timely detection or exclusion of PTHP where appropriate. This article summarises the current literature on PTHP, and sets out guidance for the screening and management of pituitary dysfunction in adult patients with TBI. It is hoped that future research will lead to more definitive recommendations in the form of guidelines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available