Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 7, Issue 16, Pages 2608-2612Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb00274j
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Funding
- National Natural Science Foundation of China [81771929]
- Key R&D Program of Tianjin [18YFZCSY01290]
- Scientific Research Instrument Developing Project of the Chinese Academy of Sciences [YJKYYQ20170067]
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DNA tetrahedron-modified silver nanoparticles (AgNPs) were achieved via amino-silver chemistry for the first time and were applied as a colorimetric biosensor for detecting HIV-related DNA. Target DNA initiated strand displacement polymerization and nicking endonuclease-aided cycles were involved to link DNA tetrahedron-modified AgNPs, reporting colorimetric responses. This developed method showed excellent specificity and sensitivity. A wide linear range from 1 to 15000 nM was achieved with a limit of detection of 0.84 nM. Moreover, it was successfully applied to determine DNA in blood serum samples.
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