Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 7, Issue 16, Pages 2678-2687Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb03299h
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Funding
- Fondazione CR Firenze
- NanoMAX-Encoder'' project (Engineering Nanostructures for Cellular Imaging and for Intracellular Delivery of Optically Active Drugs for Cardiac Hypertrophy)
- AIRC (Associazione Italiana per la Ricerca sul cancro) [19650, 19515]
- CCSG [NIH P30CA016672]
- Fondazione Cassa di Risparmio di Firenze [2016.0868]
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A drug delivery system (DDS) for combined therapy, based on a short oxidized multiwalled carbon nanotube, is reported. It was prepared by exploiting a synthetic approach which allowed loading of two drugs, doxorubicin and metformin, the targeting agent biotin and a radiolabeling tag, to enable labeling with Ga-68 or Cu-64 in order to perform an extensive biodistribution study by PET/CT. The DDS biodistribution profile changes with different administration methods. Once administered at therapeutic doses, the DDS showed a marginal beneficial effect on 4T1 tumor bearing mice, a syngeneic and orthotopic model of triple negative breast cancer, with survival extended by 1 week and 2 days in 20% of the mice. This is encouraging given the aggressiveness of the 4T1 tumor. Furthermore, our DDS was well tolerated, ruling out concerns regarding the toxicity of carbon nanotubes.
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