Journal
JOURNAL OF NEUROLOGY
Volume 264, Issue 10, Pages 2068-2074Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-017-8593-x
Keywords
Astrocyte; Alzheimer's disease; Pathogenesis
Categories
Funding
- Chongqing General Hospital
Ask authors/readers for more resources
The past several decades have given rise to more insights into the role of astrocytes in normal brain function and diseases. Astrocytes elicit an effect which may be neuroprotective or deleterious in the process of Alzheimer's disease (AD). Impairments in astrocytes and their other functions, as well as physiological reactions of astrocytes to external injury, can trigger or exacerbate hyperphosphorylated tau and amyloid-beta (A beta) pathologies, leading to the formation of both amyloid plaques and neurofibrillary tangles (NFTs), as well as neuronal dysfunction. This review addresses the involvement of astrocytes in the A beta pathology, where the main mechanisms include the generation and clearance of A beta, and the formation of NFTs. It is also discussed that metabolic dysfunction from astrocytes acts as an initiating factor in the pathogenesis of AD and a contributor to the onset and development of clinical presentation in AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available