Journal
JOURNAL OF NEUROLOGY
Volume 264, Issue 4, Pages 684-693Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-017-8403-5
Keywords
Apolipoprotein A1; Subgenual cingulum; Early Parkinson's disease; Connectometry; Diffusion MRI
Categories
Funding
- Michael J Fox Foundation for Parkinson's Research
- W Garfield Weston Foundation
- Alzheimer's Association
- Canadian Institutes for Health Research
- Natural Sciences and Engineering Research Council of Canada
- Michael J Fox Foundation for Parkinsons Research
- AbbVie
- Avid Radiopharmaceuticals
- Biogen
- Bristol-Myers Squibb
- Covance
- GE Healthcare
- Genentech
- GlaxoSmithKline (GSK)
- Eli Lilly and Company
- Lundbeck
- Merck
- Meso Scale Discovery (MSD)
- Pfizer
- Piramal Imaging
- Roche
- Servier
- UCB
Ask authors/readers for more resources
Higher plasma cholesterol levels are associated with lower Parkinson's disease (PD) risk. Apolipoprotein A-1 (ApoA-1) is a surface marker of brain HDL-like particles associated with the time of PD onset. Clinical correlates of serum Apolipoprotein A1 levels with structural brain connectivity in PD-related disorders remains unclear. Here, we applied a novel diffusion-weighted imaging approach [Diffusion Magnetic Resonance Imaging (MRI) Connectometry] to explore the association between ApoA-1 and structural brain connectivity in PD. Participants involved in this research were recruited from Parkinson's Progression Markers Initiative (PPMI). Diffusion MRI connectometry was conducted using a multiple regression against apoA-1 for 36 patients with DTI measurements available in the baseline visit. Fiber results of the connectometry were then reconstructed for each patient, and diffusion parameters were extracted and regressed against apoA-1 levels. Connectometry results revealed the subgenual cingulum to be associated with ApoA-1, with different FDR yields. This result was further supported by significant negative correlation of Quantitative Anisotropic (QA) of left subgenual cingulum (Pearson's coefficient = -0.398, p = 0.020) and Generalized Fractional Anisotropic (GFA) of right subgenual cingulum (Pearson's coefficient -0.457, p = 0.007) with plasma apoA-1 levels, in a multiple regression model with age and sex. The subgenual cingulum encompasses fibers from the anterior cingulate cortex and anterior thalamus. These structures are involved in PD-associated psychosis and executive cognitive decline. We demonstrated for the first time that apoA-1, as a blood marker, can predict microstructural changes in white matter regions in PD patients with undisturbed cognition and mild motor disability.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available