Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 313, Issue -, Pages 82-88Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2017.10.014
Keywords
Hippocampus; Cytokines; Inflammation; Epilepsy; Activated microglia
Categories
Funding
- FCT [PIC/IC/83297/2007]
- Fundação para a Ciência e a Tecnologia [2021.05161.BD, PIC/IC/83297/2007] Funding Source: FCT
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Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1 beta and IL-10 gene expression as well as the presence of activated HLA-DR + microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+ microglia and TLR4, IL-1 beta overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex.
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