Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 305, Issue -, Pages 154-161Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2017.02.003
Keywords
Parthenolide; Experimental autoimmune neuritis; Cytokines; Lymphocyte proliferation; Apoptosis
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Funding
- Taishan Scholars Construction Engineering of Shandong Province [ts20130914]
- National Natural Science Foundation of China [81471222]
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A growing body of evidence suggests the anti-inflammatory and antitumor effects of parthenolide (PAR). Here we show that PAR treatment inhibits the initiation of experimental autoimmune neuritis (EAN), suppresses the production of TNF-alpha, IFN-gamma,IL-1 beta and IL-17, and decreases Th1 and Th17 cells at early time point. However, such anti-inflammatory effect vanishes later and PAR impedes the recovery of EAN in late phase, which is accompanied with inhibited apoptosis of inflammatory cells. Our results indicate that PAR plays dual roles in EAN and it is not proper to be applied in autoimmune diseases of nervous system. (C) 2017 Elsevier B.V. All rights reserved.
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