Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 306, Issue -, Pages 25-30Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2017.02.018
Keywords
Autoimmune neurological syndrome; Paraneoplastic neurologic syndrome; Non-paraneoplastic; Autoimmune encephalitis; Neurofilament light chain; Tau protein
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Funding
- Vastra Gotalandsregionen, ALF Research Agreement. [71920]
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Autoimmune neurologic syndromes can be paraneoplastic (associated with malignancies and/or onconeural antibodies), or non-paraneoplastic Their clinical presentation is often similar. As prognosis is related to malignancy treatment, better biomarkers are needed to identify patients with malignancy. We investigated cerebrospinal fluid (CSF) markers of neuronal (neurofilament light chain, NFL and total tau protein, T-tau) and glial (glial fibrillary acidic protein) damage. CSF-NFL and T-tau were increased in both paraneoplastic and non-paraneoplastic autoimmune syndromes. Patients with manifest malignancies were older, had less epilepsy, more focal central and peripheral neurological signs and symptoms, and worse long-term outcome, than those without malignancy. CSF-NFL-levels predicted long-term outcome but were not diagnostic for malignancy, after age adjustment. (C) 2017 Elsevier B.V. All rights reserved.
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