Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 307, Issue -, Pages 1-6Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2017.03.010
Keywords
Oligoclonal IgG bands; Clinically isolated syndrome; Multiple sclerosis; Conversion; Japanese
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Funding
- Ministry of Health, Labour and Welfare of Japan
- Grants-in-Aid for Scientific Research [17K11477] Funding Source: KAKEN
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We evaluated the impact of brain MRI findings and oligoclonal IgG bands (OCBs) on conversion to clinically definite multiple sclerosis (CDMS) in 26 Japanese patients with clinically isolated syndrome (CIS). 19.2% had OCBs positivity and 3.8% had fulfillment of Barlchof criteria at baseline. 60.0% of CIS patients with positive OCBs and 9.5% of those with negative OCBs developed CDMS during 60.6 months. Japanese CIS patients with positive OCBs have an equivalent risk of developing CDMS. A hypothesis that Japanese CIS patients may have substantially less OCBs positivity, MRI lesions, and conversion ratio than Caucasians, should be further tested. (C) 2017 Elsevier B.V. All rights reserved.
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