Journal
OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS
Volume 11, Issue -, Pages 253-267Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OARRR.S165916
Keywords
environmental exposure; risk factors; juvenile arthritis; antibiotics; breast feeding; cesarean section
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Funding
- NIAMS NIH HHS [K23 AR070286] Funding Source: Medline
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Juvenile idiopathic arthritis is a common rheumatic disease that presents as chronic childhood arthritis. JIA is considered a multifactorial disease that may result from diverse genetic and environmental risk factors. A minority of the population-attributable risk of JIA is estimated to be due to familial factors. Thus, non-genetic or environmental factors likely account for a majority of the risk of developing JIA. Yet, while substantial data have linked environmental factors to the development of rheumatoid arthritis, similar evidence regarding JIA is sparse. This narrative review provides updates on recent literature about environmental factors that might influence the risk of developing JIA, including studies about potentially beneficial and harmful influences as well as factors with unclear effects.
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