Journal
JOURNAL OF NEUROCHEMISTRY
Volume 142, Issue -, Pages 111-121Publisher
WILEY
DOI: 10.1111/jnc.14052
Keywords
ACh; AD; cholinergic; hippocampus; learning; memory; muscarinic; nicotinic
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Funding
- NIEHS/NIH intramural research program [Z01-ES090089]
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Acetylcholine (ACh) plays an important role in memory function and has been implicated in aging-related dementia, in which the impairment of hippocampus-dependent learning strongly manifests. Cholinergic neurons densely innervate the hippocampus, mediating the formation of episodic as well as semantic memory. Here, we will review recent findings on acetylcholine's modulation of memory function, with a particular focus on hippocampus-dependent learning, and the circuits involved. In addition, we will discuss the complexity of ACh actions in memory function to better understand the physiological role of ACh in memory.
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