Journal
JOURNAL OF NEURAL ENGINEERING
Volume 14, Issue 3, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1741-2552/aa60b3
Keywords
optogenetics; electrophysiology; implantable optoelectronic probes; multi photon imaging; optrode; optetrode; transparent electrodes
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Funding
- Office of Naval Research Young Investigator Award
- UC San Diego Frontiers of Innovation Scholars Program
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More than a decade has passed since optics and genetics came together and lead to the emerging technologies of optogenetics. The advent of light-sensitive opsins made it possible to optically trigger the neurons into activation or inhibition by using visible light. The importance of spatiotemporally isolating a segment of a neural network and controlling nervous signaling in a precise manner has driven neuroscience researchers and engineers to invest great efforts in designing high precision in vivo implantable devices. These efforts have focused on delivery of sufficient power to deep brain regions, while monitoring neural activity with high resolution and fidelity. In this review, we report the progress made in the field of hybrid optoelectronic neural interfaces that combine optical stimulation with electrophysiological recordings. Different approaches that incorporate optical or electrical components on implantable devices are discussed in detail. Advantages of various different designs as well as practical and fundamental limitations are summarized to illuminate the future of neurotechnology development.
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