Journal
JOURNAL OF TISSUE ENGINEERING
Volume 10, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/2041731419884708
Keywords
Tissue engineering; insulin-producing cell; artificial organ; endocrine pancreas; evidence map
Categories
Funding
- EU Horizon 2020 Eurostars-2 [E!12021]
- Deutsche Forschungsgemeinschaft within the funding program Open Access Publishing
Ask authors/readers for more resources
A bioartificial endocrine pancreas is proposed as a future alternative to current treatment options. Patients with insulin-secretion deficiency might benefit. This is the first systematic review that provides an overview of scaffold materials and techniques for insulin-secreting cells or cells to be differentiated into insulin-secreting cells. An electronic literature survey was conducted in PubMed/MEDLINE and Web of Science, limited to the past 10 years. A total of 197 articles investigating 60 different materials met the inclusion criteria. The extracted data on materials, cell types, study design, and transplantation sites were plotted into two evidence gap maps. Integral parts of the tissue engineering network such as fabrication technique, extracellular matrix, vascularization, immunoprotection, suitable transplantation sites, and the use of stem cells are highlighted. This systematic review provides an evidence-based structure for future studies. Accumulating evidence shows that scaffold-based tissue engineering can enhance the viability and function or differentiation of insulin-secreting cells both in vitro and in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available