Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 2, Pages 544-550Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b01073
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Funding
- National Natural Science Foundation of China [31401473, 81570788, 81341102]
- Fundamental Research Funds for Northeastern University, People's Republic of China [N142005002, N142002001, N120820002, N130220001]
- Program for New Century Excellent Talents in Northeastern University
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Fifteen new phloroglucinol derivatives, jamunones A-O (1-8 and 10-16, respectively), along with one known analogue spiralisone C (9), were isolated from Eugenia jambolana seeds. Their structures were elucidated by detailed nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Compounds 1-9, 11, 12, and 14-16 inhibited protein tyrosine phosphatase 1B activity with IC50 values ranging from 0.42 to 3.2 mu M.
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