Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 12, Pages 3168-3172Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00417
Keywords
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Funding
- National Natural Science Foundation of China [21372208, 21542001, 41676127]
- Shandong Provincial Natural Science Fund for Distinguished Young Scholars [JQ201422]
- AoShan Talents Program - Qingdao National Laboratory for Marine Science and Technology [2015ASTP-ES09]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02]
- Shandong province key research and development program [2016GSF201204]
- Fundamental Research Funds for the Central Universities [201564026]
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Four new polyketides, penitalarins A-C (1-3) and nafuredin B (4), together with the known biogenetically related nafuredin A (5) were isolated from a mixed culture of a deep-sea-derived fungus Talaromyces aculeatus and a mangrove-derived fungus Penicillium variabile. Liquid chromatography/mass spectrometry analysis showed that none of compounds 1-5 was produced by either of the two fungi when cultured alone under the same condition. The structures of 1-4, including absolute configurations, were deduced based on the interpretation of MS, NMR data, and time-dependent density functional theory calculations of specific electronic circular dichroism spectra. Compounds 1-3 possess a 3,6-dioxabicyclo[3.1.0]hexane ring, and 4 showed cytotoxicity with IC50 values ranging from 1.2 to 9.8 mu M against a panel of human cancer cell lines.
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