Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 12, Pages 3320-3324Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00679
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Funding
- International Foundation for Science (IFS) [F/5376-1]
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Two new chlorine-containing polyoxygenated seco-cyclohexenes, albanols A (1) and B (2), along with the oxepinone metabolite grandiuvarone (3) were isolated from the endemic Philippine Annonaceae plant Uvaria alba. Both new compounds exhibited modest antitubercular activity. Compound 1 showed cytostatic activity (ranging from 1-50 mu M) against HeLa cells and weak antiproliferative activity against HUVEC and K-562 cells with GI50 values of 106 and 81 mu M, respectively.
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