Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 12, Pages 3104-3112Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b01127
Keywords
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Funding
- 'Ten Diseases amp
- Ten Drugs' Project of Beijing Municipal Science amp
- Technology Commission [Z171100001717009]
- National Natural Science Foundation of China [81473119, 81473590, 81402814]
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Fifteen new and rare iridoid glucoside dimers, cornusides A-O (1-15), and 10 known iridoid glucosides (16-25) were isolated from the fruit of Cornus officinalis. These new chemical structures were estabhshed through spectroscopic analysis (UV, IR, HRESIMS, ID and 2D NMR). Compounds 1-25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC50 values of 11.9, 12.2, 14.0, 7.0, and 6.9 mu M, respectively.
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