Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 9, Pages 2492-2501Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00370
Keywords
-
Funding
- National Council for Scientific and Technological Development (CNPq) [311048/2016-1]
- Sao Paulo Research Foundation (FAPESP) [014/50420-9]
- FAPESP [2012/25272-0, 2016/07490-1]
Ask authors/readers for more resources
Chemical investigations of the terrestrial cyanobacterium Sphaerospermopsis torques-reginae ITEP-024 from northern Brazil afforded namalides B (1) and C (2), the first analogues of this anabaenopeptide-like metabolite to be described. Four other related peptides (3-6), termed spumigins K-N, were also identified. Planar structures and absolute configurations for 1, 2, and 3a-6a were deduced by a combination of 2D NMR, HRMS analysis, and Marfey's methodology. Spumigins K-N (3-6) are the first examples of spumigins containing a 2-hydroxy-4-(4-hydroxypheny1)butanoic acid (Hhpba) in the N-terminal position. Compounds 1 and 2 inhibited carboxypeptidase A with IC50 values of 0.75 and 2.0 mu M, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available