Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 43, Pages 9514-9523Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob01700c
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Funding
- UGC [BSR/CH/16-17/0174]
- SERB, India [EMR/2016/002193]
- Department of Science and Technology (DST), India under FIST programme
- UGC, India, under CAS-II programme
- UGC, India, under UPE programme
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An efficient asymmetric organocatalytic conjugate addition reaction of pyrazolin-5-ones with arylomethylidene malonates has been successfully developed by employing bifunctional Cinchona derived thiourea organocatalysts. The protocol provides straightforward access to pyrazole substituted scaffolds in good yields with high stereocontrol.
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