Journal
NEW JOURNAL OF CHEMISTRY
Volume 43, Issue 43, Pages 16945-16949Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nj03744f
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Funding
- NSFC [21472067, 21672083, 21877048]
- Taishan Scholar Foundation [TS201511041]
- University of Jinan [309-10004]
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A two-photon fluorescent probe, Mito-V, was designed and prepared for sensing the viscosity changes of mitochondria. The systematic investigations demonstrated that the fluorescence emission at 634 nm increased about 22-fold from methanol to 99% glycerol, indicating high viscosity dependence. Notably, using the probe, the mitochondrial viscosity fluctuations have been successfully monitored not only in living cells but also in zebrafish and living mice.
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