4.7 Article

Lamellodysidines A and B, Sesquiterpenes Isolated from the Marine Sponge Lamellodysidea herbacea

Journal

JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 9, Pages 2536-2541

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00610

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Funding

  1. Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan. [22406001, 17H03994]
  2. Grants-in-Aid for Scientific Research [17K19497, 17H03994, 22406001] Funding Source: KAKEN

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Four new sesquiterpenes, lamellodysidines A and B, O,O-dimethyllingshuiolide A, and 11-epi-O,O-dimethyllingshuiolide A (1-4), were obtained from the marine sponge, Lamellodysidea herbacea, collected in Indonesia. Their planar structures were elucidated by analysis of spectroscopic data. The absolute configurations of the new compounds were determined by the calculated ECD spectra. Compound 1 has a unique carbon framework, and 2 is a new nitrogenous sesquiterpene.

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