Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 87, Pages 13168-13171Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc07482a
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Funding
- National Natural Science Foundation of China [21572130, 21871179]
- Shanghai Jiao Tong University
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An efficient method for the asymmetric synthesis of N-substituted 2-pyridones via Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones has been developed. By using a palladium complex in situ generated from Pd-2(dba)(3)center dot CHCl3 and phosphoramidite L2 as a ligand, the process allowed rapid access to N-substituted 2-pyridones with complete chemo- and regioselectivities and good to high enantioselectivities.
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