Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 87, Pages 13066-13069Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc06563f
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Funding
- Natural Science Foundation of China [21401031, 21431001, 81473102]
- Natural Science Foundation of Guangxi Province [2015GXNSFAA139043, 2016GXNSFGA380005]
- Fundamental Research Funds for the Central Universities, Guangdong Key Lab of Chiral Molecule and Drug Discovery [2019B030301005]
- Shenzhen Fundamental Research Fund [JCYJ20180508163206306]
- [IRT_16R15]
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A platinum(II) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent antitumour activities in two independent mouse models via an immunogenic cell death pathway.
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