Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 17, Issue 12, Pages 8797-8805Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2017.13875
Keywords
Chitosan; Nanocomposites; Antibacterial Agents; Water Disinfection
Categories
Funding
- Department of Science and Technology, Government of India [DST/TM/WTI/2K13/94 (G)]
- Ministry of Human Resource Development, Government of India
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The burgeoning antibiotic resistance of the bacteria has encouraged the researchers globally to develop new antimicrobial agents. Herein, we have developed nanocomposites (NCs) by coating chitosan (ch) onto the silver-zinc oxide nanocomposites through microwave assisted in situ approach, obtaining Ag@ZnO-ch NCs as a novel biopolymer coated antimicrobial agent. The surface morphology, crystalline structure and the functional groups of the nanocomposites were characterized by using field emission scanning electron microscopy (FE-SEM), X-ray diffraction measurements (XRD) and Fourier transform infrared spectroscopy (FTIR). The minimum inhibitory concentration (MIC) and the minimum killing concentration (MKC) of the Ag@ZnO-ch NCs showed excellent antibacterial activity towards both Gram-positive bacteria Staphylococcus aureus (S. aureus) and Gram-negative bacteria recombinant green fluorescent protein (GFP) expressing antibiotic resistant Escherichia coli (E. coli). Further investigation of the antibacterial activity against the live water samples revealed that the Ag@ZnO-ch NCs treatment exhibited the similar antibacterial efficacy by inhibiting the bacterial growth. Also the MKC value of Ag@ZnO-ch NCs against S. aureus and GFP E. coli was 30 mu g/mL and 300 mu g/mL, respectively. Compared to the silver and zinc oxide based nanocomposites which have been widely used as antibacterial agents, our chitosan coated Ag@ZnO-ch NCs exhibited better antibacterial efficacy. Therefore, we proposed that the polymer coated metal-metal oxide nanocomposites is quite a promising antibacterial agent, suitable for the water purification applications.
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