Journal
DATA IN BRIEF
Volume 26, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.dib.2019.104464
Keywords
Silver nanoparticles; Epithelial cells; Basement membrane; Extracellular matrix; TGF-Beta; Intracellular signalling pathway analysis
Categories
Funding
- NIEHS [P30ES025128]
- NCI [U54 CA156735]
- Komen Foundation [GTDR16377604]
- NIMHD [U54 MD012392]
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This data article is related to the research article entitled Silver nanoparticles alter epithelial basement membrane integrity, cell adhesion molecule expression and TGF-beta secretion, available in the journal Nanomedicine: Nanotechnology, Biology, and Medicine [1]. This Data in Brief consists of data that describe changes in the expression of basement membrane (BM)-associated genes and proteins in three non-transformed epithelial cell lines following acute (6 h) and chronic (24 h plus 7-day chase) exposure to silver nanoparticles (AgNPs). Human BEAS2B (lung), MCF10AI (breast), and CCD-18Co (colon) cultured epithelia were analyzed for protein expression by LC-MS/MS and for gene expression by pathway-focused QRT-PCR arrays of 168 focal adhesion, integrin, and extracellular matrix (ECM) genes known to be localized to the plasma membrane, the BM/ECM, or secreted into the extracellular space. Ingenuity pathway analysis (IPA) of combined gene and protein expression datasets was then used to predict canonical pathways affected by AgNP exposure. (C) 2019 The Author(s). Published by Elsevier Inc.
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