Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 17, Issue 10, Pages 7775-7782Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2017.14838
Keywords
Porous Microspheres; Porosity; Size Distribution; Solvent Effects; Porogens
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Funding
- National Research Foundation of Korea Grant - Korean Government (KMEST) [NRF-2012M3A9C6050112]
- National Research Foundation of Korea [2012M3A9C6050112, 21A20131700001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, we analyzed the effects of four solvents-dimethylcarbonate (DMC), ethylacetate (EA), dichloromethane (DCM), and chloroform (CH)-on the porosity and size of porous PLGA microspheres produced using aqueous gelatin and phosphate-buffered saline (PBS) as porogens in a microfluidic flow-focusing (MFF) device. Relatively water soluble solvent such as DMC and EA miscible with aqueous porogen solution/porogen, did not produce porous microspheres, while poor water soluble solvents such as DCM and CH produced highly porous microspheres. Furthermore, as the immiscibility of the polymer solution and porogen increased, the porosity and pore size also increased. Similarly, the highly volatile solvents (DCM and CH) resulted in smaller microspheres than EA and DMC, which are less volatile. The porosity of porous microspheres also depended on the porogen. Aqueous gelatin produced highly porous microspheres, while PBS resulted in smaller pore sizes.
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