Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 19, Issue 2, Pages -Publisher
SPRINGER
DOI: 10.1007/s11051-017-3754-5
Keywords
Magnetic nanoparticles; Controlled release; Modeling; Drug delivery; Drug release acceleration
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Funding
- Russian Science Foundation [14-13-00731]
- Ministry of Education and Science of the Russian Federation [K1-2014-022]
- Russian Science Foundation [14-13-00731] Funding Source: Russian Science Foundation
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Various plausible acceleration mechanisms of drug release from nanocarriers composed of a single-domain magnetic nanoparticle core with attached long macromolecule chains activated by low frequency non-heating alternating magnetic field (AMF) are discussed. The most important system characteristics affecting the AMF exposure impact are determined. Impact of several reasonable mechanisms is estimated analytically or obtained using numerical modeling. Some conditions providing manifold release acceleration as a result from exposure in AMF are found.
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