Journal
ISCIENCE
Volume 21, Issue -, Pages 288-+Publisher
CELL PRESS
DOI: 10.1016/j.isci.2019.10.033
Keywords
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Categories
Funding
- DAE [21/01/2016-BRNS/35074]
- DBT [BT/PR13458/COE/34/33/2015, BT/PR13616/GET119/9/2015-DBT]
- IFCP [IFC/5203-4/2015/131]
- IISc-DBT partnership program [DBT/BF/PR/INS/2011-12/IISc]
- DST [SR/FST/LSI-536/2012-DST-FIST]
- IISc
- CSIR
- DBT, India
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DNA, the fundamental unit of human cell, generally exists in Watson-Crick base-paired B-DNA form. Often, DNA folds into non-B forms, such as four-stranded G-quadruplexes. It is generally believed that ionizing radiation (IR) induces DNA strand-breaks in a random manner. Here, we show that regions of DNA enriched in G-quadruplex structures are less sensitive to IR compared with B-DNA in vitro and inside cells. Planar G-quartet of G4-DNA is shielded from IR-induced free radicals, unlike single- and double-stranded DNA. Whole-genome sequence analysis and real-time PCR reveal that genomic regions abundant in G4-DNA are protected from radiation-induced breaks and can be modulated by G4 stabilizers. Thus, our results reveal that formation of G4 structures contribute toward differential radiosensitivity of the human genome.
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