Journal
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
Volume 38, Issue 1, Pages 37-45Publisher
SPRINGER
DOI: 10.1007/s10974-017-9470-z
Keywords
Calcium; Excitation-contraction coupling; Muscular dystrophy; RyR1; Skeletal muscle
Categories
Funding
- NIH [R01AR060037, R01HL061503, K99DK107895]
- Fondation Leducq
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL061503] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR060037] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K99DK107895] Funding Source: NIH RePORTER
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Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation-contraction (E-C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.
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